Isogenica’s Blogs

2-for-1 VHH antibody engineering

2-for-1 VHH antibody engineering

When a partner needed VHH antibody engineering fast, we developed a method to humanise and affinity mature the antibodies in a single step.

VHH Humanisation

VHH Humanisation

VHH humanisation can be a challenge. Here, we compare two methods – safe-but-slow rational humanisation and fast-but-risky CDR grafting. We also explore the impact of synthetic versus immune-derived frameworks.

The golden age of bi-specific antibodies is here

The golden age of bi-specific antibodies is here

Bi-specific antibodies (BsAbs) – antibodies that can recognise two different epitopes on either the same or different antigens – have been around for a long time. However, in the past few years we’ve seen a renaissance in the design and application of these molecules.

Isogenica turns 25: Our journey

Isogenica turns 25: Our journey

We’ve come a long way over the past quarter century, from our early years as a therapeutic peptide discovery company to specialising in VHH antibodies. Here’s the story…