CIS display is an antibody selection tool and alternative to traditional phage display methods.
Unlike phage, yeast, or mammalian display, CIS display does not involve a biological system. This means that library sizes are less restricted and that larger libraries can be mined effectively.
Originally developed by a team at Isogenica including our current CEO Dr. Bill Eldridge, CIS display was first designed to interrogate high-diversity peptide libraries. Over time, this was extended very successfully to increasingly complex small format scaffolds such as Centyrins and VHHs.
CIS display, a DNA-based in vitro selection technology for therapeutic peptides
CIS display is a DNA-based in vitro display technology that enables the display and selection of peptides and proteins from extremely large libraries…
CIS display: In vitro selection of peptides from libraries of protein–DNA complexes
PNAS published February 23, 2004. 101 (9) 2806-2810