Learn about CIS display, a powerful antibody selection tool
CIS display is a cell-free alternative to traditional phage display methods. Uncover the power of an antibody selection tool optimized for our ultra high-diversity libraries and advanced small format scaffolds like Centyrins and VHHs
What is CIS display?
Unlike phage, yeast, or mammalian display, CIS display does not involve a biological system. This means that library sizes are less restricted and that larger libraries can be mined effectively.
Originally developed by a team at Isogenica including our current CEO Dr. Bill Eldridge, CIS display was first designed to interrogate high-diversity peptide libraries. Over time, this was extended very successfully to increasingly complex small format scaffolds such as Centyrins and VHHs.
Why do we use CIS display?
CIS display is the perfect partner for our synthetic libraries to enable much faster antibody discovery compared to immunisation. To learn more, get in touch today.
Publications
CIS display, a DNA-based in vitro selection technology for therapeutic peptides
CIS display is a DNA-based in vitro display technology that enables the display and selection of peptides and proteins from extremely large libraries…
CIS display: In vitro selection of peptides from libraries of protein–DNA complexes
PNAS published February 23, 2004. 101 (9) 2806-2810