Research-Focused Blog Posts
Our blog posts offer concise, expert commentary on the latest developments in VHH technology. From new research findings to industry updates and practical tips, each article is written to inform and support your scientific work.
Isogenica named in Business Weekly’s Ones2Watch
Isogenica, a specialist in synthetic VHH antibody discovery, was recognised in the Ones2Watch category for its scientific credibility and commercial momentum.
Building the next generation of precision oncology medicines
Biologic therapies have reshaped oncology, but they come with real limitations. Traditional monoclonal antibodies are large, complex molecules that can struggle with tumor penetration, slow development timelines, and costly manufacturing. In a field where time is critical and healthcare budgets are under increasing pressure, these constraints can hold back promising innovations. Read the article.
Avoiding Freedom-to-Operate Pitfalls in Antibody Discovery
Conventional immunization-based discovery techniques frequently result in overlapping sequences with intellectual property (IP) concerns, due to the high number of antibody sequences already patented. These limitations can restrict opportunities for development, increase legal uncertainty, and reduce commercial viability.
Why Biotech Leaders Choose Cambridge UK for Antibody Discovery
This case study delves into the development of anti-LRP6 VHH inhibitors that overcome these challenges. Isogenica’s VHH technology offers hope for more effective therapies targeting Wnt-related cancers.
Comparing Risk in Synthetic vs Immune-based Discovery: Why Synthetic VHH Antibodies are the Future of Antibody Discovery
This case study delves into the development of anti-LRP6 VHH inhibitors that overcome these challenges. Isogenica’s VHH technology offers hope for more effective therapies targeting Wnt-related cancers.
Anti-LRP6 VHHs: Precision Targeting of the Wnt Pathway for Cancer Therapy
This case study delves into the development of anti-LRP6 VHH inhibitors that overcome these challenges. Isogenica’s VHH technology offers hope for more effective therapies targeting Wnt-related cancers.
Solid Tumour Targeting – VHH antibodies as building blocks for advanced cancer therapies
Cancer continues to pose a significant challenge in the realm of biomedical research, particularly with respect to solid tumors, which constitute over 90% of adult cancer cases.But what makes solid tumors so challenging? And what solutions are available to overcome...
Unlocking Affordable Biologics: VHH Antibodies in Baker’s Yeast
The production of traditional IgG monoclonal antibodies has long been hindered by their complexity. These molecules require complex and costly manufacturing processes, with estimated production costs ranging from $95 to $200 per gram. As well as contributing to issues...
From monoclonals to bi-specifics: Harnessing the transformative power of VHHs to supercharge IgG therapeutics
We explain how VHHs – small format single-domain antibody fragments – have a range of unique properties that make them ideal for enhancing the therapeutic potential of conventional IgG antibodies.
Challenging assumptions in antigen QC for antibody discovery success
Not all projects go as planned, but breakthroughs often emerge from the most unexpected challenges. This case study explores how a technical obstacle during early QC could have derailed a VHH discovery project - but turned into a demonstration of collaboration,...