Antibody Discovery Services
Accelerate your research with our expert VHH (nanobody) antibody discovery services.
Start your discovery with us
Isogenica’s solutions are designed to maximise the overall success of your drug development projects by providing the right solutions with significantly reduced timelines, mitigated risks, and a clear path to IP. These strategies ensure that our partners achieve not just short-term milestones but long-term commercial success.
VHH Antibody Discovery
- VHH antibody discovery from the world’s largest libraries translating into greater binder diversity and avoiding sequence collapse
- Pre-humanised libraries to accelerate timelines
- Antigen biotinylation and QC
- CIS and phage display selections
- High throughput primary screening reinforced by NGS sequencing and analysis
VHH Characterisation
- VHH Characterisation
- High-throughput expression
- Affinity measurement and epitope binning
- Biophisical profiling: aSEC, Tm, etc.
- Specificity and cross-reactivity
Custom Assay Development
- Functional assays (antagonism, internalisation, cell killing)
- Primary cell testing
- Multimerization, humanisation (if needed)
- Tags and payload handle integration
VHH Antibody Engineering
- Rapid bi-specific building and assessment
- Humanisation of synthetic or immune-derived VHHs (if needed)
- Affinity maturation
- Tags and payload handles (e.g. sortase, free-cysteine)
Work with us
By partnering with our expert team, you’ll access an ecosystem of deep expertise and state-of-the-art technology combined with an open and cooperative working relationship. From start to finish we become an extended part of your team, keeping you updated and informed regularly on our progress in integrating our relative areas of expertise to achieve the strongest results. With our groundbreaking technology and expert guidance, Isogenica helps small to mid-sized biotech companies bring novel therapies to market faster— cutting typical discovery timelines in half by accelerating lead selection and reducing follow-on engineering requirements. Talk to us today and find out how we can accelerate your VHH discovery project.