VHH Multi-specific

Plug-and-Play Platform

Efficient generation of bi- and tri-specific VHH next-generation biotherapeutics supported by a pipeline of developable VHHs.

Isogenica have developed fully synthetic, in vitro plug-and-play cassette-based approach to efficiently generate combinations of bi- and tri-specific VHH and have exemplified this in in vitro studies.

  • Isogenica’s libraries ensure standardised flanking sequences that can be easily slotted into bi- and tri-specific expression cassettes
  • Cross-species specific anti-albumin VHH binds to protein A to simplify downstream CMC
  • Production in mammalian expression systems and scaled-up purification facilitates developability and functional testing, including T-cell activation

Advantages of VHH in


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