Appetite for destruction: ‘Plug and play’ targeted protein degradation using synthetic VHH antibodies to take out tricky targets A recent study demonstrating the effectiveness of single domain antibody-directed protein degradation adds to this new and expanding...
‘Intrabodies’ – Isogenica’s VHH antibodies improve heart function when delivered intracellularly Our VHH antibodies have been put to the test as a potential new therapy for heart failure in an early-stage study from AstraZeneca published in...
2-for-1 VHH antibody engineering Humanising and improving antibody affinity all in one step Sometimes the smallest of molecules pose the greatest challenges. This was the case when a partner approached us with what turned out to be a VHH antibody engineering...
VHH Humanisation Unlike conventional IgG antibodies from humans or mice, VHHs (also known as nanobodies) are composed solely of the single variable domain of a heavy chain. Originally derived from llamas, VHH antibody humanisation is often required. Here we compare...
