by Isogenica Webmaster | Jun 2024 | Blogs, Case studies
Appetite for destruction: ‘Plug and play’ targeted protein degradation using synthetic VHH antibodies to take out tricky targets A recent study demonstrating the effectiveness of single domain antibody-directed protein degradation adds to this new and expanding...
by Isogenica Webmaster | Jun 2024 | Blogs, Case studies, Intrabodies blog
‘Intrabodies’ – Isogenica’s VHH antibodies improve heart function when delivered intracellularly Our VHH antibodies have been put to the test as a potential new therapy for heart failure in an early-stage study from AstraZeneca published in...
by Isogenica Webmaster | May 2024 | Blogs, Case studies, VHH Affinity Maturation and Engineering
2-for-1 VHH antibody engineering Humanising and improving antibody affinity all in one step Sometimes the smallest of molecules pose the greatest challenges. This was the case when a partner approached us with what turned out to be a VHH antibody engineering...
by Isogenica Webmaster | May 2024 | Bi-specific resources, Blogs, VHH Affinity Maturation and Engineering, VHHs
VHH Humanisation Unlike conventional IgG antibodies from humans or mice, VHHs (also known as nanobodies) are composed solely of the single variable domain of a heavy chain. Originally derived from llamas, VHH antibody humanisation is often required. Here we compare...
