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From monoclonals to bi-specifics: Harnessing the transformative power of VHHs to supercharge IgG therapeutics
We explain how VHHs – small format single-domain antibody fragments – have a range of unique properties that make them ideal for enhancing the therapeutic potential of conventional IgG antibodies.
Challenging assumptions in antigen QC for antibody discovery success
Not all projects go as planned, but breakthroughs often emerge from the most unexpected challenges. This case study explores how a technical obstacle during early QC could have derailed a VHH...
Synthetic Biology Technologies for Antibody Discovery
Imagine bypassing the lengthy traditional immunization process and tapping into the antibody diversity equivalent of over a million llamas – right at your fingertips. Synthetic Biology Technologies are transforming antibody discovery, accelerating the design of targeted therapies with greater precision, speed, and reduced risk. Read now!
Nanobody or VHH – What’s the difference?
In the realm of biotechnology and medicine, the terms nanobody and VHH are often used interchangeably to describe single-domain antibodies. These small-format versions of traditional antibodies have grown as cornerstones of scientific innovation from diagnostics to cell and gene therapies. But where do these names come from, and what meanings do they have for describing what makes them so pivotal in today’s research and therapeutic applications?
Tools for ADC drug discovery – screening VHHs with pre-engineered C-terminal cysteine handles
Isogenica developed a screening approach using pre-engineered C-terminal Cysteine handles. VHHs expressed well in this format and formed spontaneous stable dimers. This approach can now be applied to future projects which require VHH antibody conjugation for ADC and other applications.
Specific Antibodies to Difficult Targets: How to find the needles in the haystack
Peptides, often small and unstructured, are some of the most difficult targets in antibody discovery. Here, we recount how we tweaked our approach to mining our vast VHH libraries to isolate highly specific binders for difficult targets like these, even when other methods had failed.
Explore the science behind our antibody discovery platforms
White Paper “Data-Driven Validation of Synthetic VHHs”
This white paper provides a data-driven validation of Isogenica’s synthetic VHH libraries, powered by Colibra® technology. Designed for biotech and pharmaceutical scientists, it demonstrates how these libraries enhance and accelerate drug discovery, particularly in oncology and immunotherapy. Download Extending half-lives of VHH antibodies
Because VHHs are small, they can be cleared quickly from the bloodstream. This can be a useful feature for some applications, but often a longer plasma half-life is desirable. DOWNLOADAdvantages of VHH in bi-specifics
To learn more about the application of VHHs in bi-specifics, we have condensed our expertise into a downloadable Application Note. DOWNLOADOptimizing CAR-T and T-cell antibody engagers: a role for VHH single domain antibodies
This whitepaper summarises the clinical and research landscape for CAR-T and T-cell engaging antibody therapies and show how single domain VHH antibodies can be applied to optimise the next generation of these important new therapeutic modalities. DOWNLOADIsogenica’s PD-L1 VHH as Functional Antagonists
PD-1 is an immune checkpoint protein expressed on the surface of multiple types of immune cells, including antigen-stimulated T-cells and tumour specific T-cells1. Interaction between PD-1 and its ligands (PD-L1 or PD-L2), is responsible for the regulation of T-cell activation, apoptosis, proliferation and cytokine production. DOWNLOADAnti-LRP5/6 VHH inhibits WNT pathway and prevents tumour growth
VHH are the variable domain of heavy chain only antibodies. They are small in size (~15 kD) and biophysically robust. With tunable half-lives, these antibodies are ideal for targeting inaccessible epitopes, achieving enhanced tissue penetration, multi-target binding and formatting for payload delivery… DOWNLOAD