How target presentation and environment shape epitope access, selection outcomes, and functional screening
Join Isogenica for a technical webinar on challenging membrane targets
On 10 April 2026 at 4 pm (UK time), Isogenica will host a partner-led webinar focused on one of the most persistent challenges in antibody discovery: translating hits into functional, mechanism-relevant outcomes for complex membrane targets. Targets such as GPCRs, ion channels, multi-pass transmembrane proteins, and multi-component systems like CD3–TCR frequently fail early in discovery workflows. This is often driven by the fact that target presentation and biological environment determine which conformations and epitopes are accessible. The result is a familiar failure mode: selections enrich the wrong binders, and functional screens produce misleading readouts that do not translate downstream.. This session introduces a practical framework to address these issues earlier in discovery. By aligning target, environment, and MOA from the outset, teams can reduce false positives, improve interpretation of screening data, and make more informed progression decisions. Attendees will leave with practical decision criteria for choosing presentation formats and early screening approaches for challenging membrane targets. Session Takeaways
- De-risk translation between panning and screening: how conformation, environment, and presentation create format-dependent epitope access
- Building your own Nanodisc workflows: practical considerations and example workflows (including CD3–TCR) to preserve native-like structures and improve epitope accessibility for discovery and functional screening
Speakers
- Rosie Dawaliby (Co-founder & CEO, G.CLIPS) – will introduce the Target–Environment–MOA triad for discovering and validating conformation- and pathology-sensitive candidates
- Anil Kumar (Business Development Manager, KACTUS Bio) – will share how nanodisc-based antigen presentation can preserve native-like structure and improve access to cryptic and conformational epitopes, including challenging membrane proteins and CD3–TCR complexes, with practical considerations and example workflows supporting antibody discovery and functional screening
- Jessica Kaplunov (Director of Business Development, Isogenica) – will bring perspective on aligning discovery strategies with programme needs
This webinar is designed for teams working on complex or high-risk targets where conventional approaches often lead to poor translation. The session focuses on practical decision-making criteria and experimentally grounded strategies to improve discovery outcomes. Secure your place and explore how to better align target biology with discovery strategy for challenging membrane systems.